The effects on a fetus or neonate are unknown, hence these drugs are not prescribed in pregnancy or breast feeding mothers. Contraindications ĭirect Xa inhibitors are contraindicated in people who are actively bleeding or who are at high risk of bleeding. Factors considered before deciding on whether warfarin or a DOAC or which direct factor Xa inhibitor is used, include: the presence or absence of valvular heart disease, state of kidney function, the risk of stroke and the risk of bleeding. ĭirect factor Xa inhibitors can be considered as an alternative to warfarin, particularly if a person is on several other medications that interact with warfarin, or if attending medical appointments and laboratory monitoring becomes difficult. They are commonly prescribed to treat and prevent blood clots in veins, prevent stroke and embolism in people with non-valvular atrial fibrillation (AF) who have other risk factors, and prevent blood clots after routine knee and hip replacement surgery. Medical use ĭirect factor Xa inhibitors include rivaroxaban, apixaban and edoxaban, and are types of direct oral anticoagulant, which are blood thinning drugs, one of the classes of antithrombotic drugs. Inhibit fibrin formation in the final common pathway of the coagulation cascadeĭirect factor Xa inhibitors ( xabans) are anticoagulants (blood thinning drugs), used to both treat and prevent blood clots in veins, and prevent stroke and embolism in people with atrial fibrillation (AF). Direct Xa inhibitor, novel oral anticoagulant
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